PH Grand Rounds: Interferon-Associated Pulmonary Arterial Hypertension

Hypertension Grand Rounds Gitelman Syndrome

Gitelman syndrome (GS) is an autosomal-recessive renal tubular disorder characterized by hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis, secondary hyperreninemic aldosteronism, and low blood pressure.1–3 GS patients are usually diagnosed relatively late, because malaise, low blood pressure, hypokalemia, hypocalciuria, and hypomagnesemia are difficult to categorize clinically. I...

Thalassemia Associated Pulmonary Hypertension

Cardiac disease is the main cause of death in both forms of thalassemia; thalassemia major (TM) and thalassemia intermedia (TI). Pulmonary hypertension (PH) is one of the cardiopulmonary morbidities with high mortality that, if not treated, may trigger right-sided heart failure and premature death. PH is defined as a mean pulmonary artery pressure of ≥25 mmHg at rest or ≥30 mmHg during exercise...

Hypertension Grand Rounds Severe Hypertension With Large-Vessel Arteritis

Small-vessel arteritis is associated with hypertension because the commonest varieties, granulomatous vasculitis with polyangitis and microscopic polyangitis with antineutrophil cytoplasmic autoantibodies, usually cause necrotizing glomerular disease. Medium vessel vasculitis, such as polyarteritis nodosa and Kawasaki disease, are less regularly associated with hypertension. Large-vessel vascul...

Hypertension Grand Rounds Management of Antiangiogenic Therapy-Induced Hypertension

Angiogenesis, or the formation of new blood vessels, is essential for solid tumor growth and metastasis, and it is regulated by proangiogenic soluble mediators, including the vascular endothelial growth factor (VEGF). Antiangiogenic drugs that block the VEGF signaling pathway prolong progression-free survival (PFS) in several cancers and are now in broad clinical use to treat advanced-stage sol...

Grand rounds.